Maria Francesca wanted to be a sister but was unable to enter the convent. She began working in an orphanage in Italy. The bishop noticed her devotion and holiness and eventually allowed her to make her vows. She noticed that immigrants were in need of help, so she asked the bishop if she could form a group of sisters to serve them. She and her sisters traveled to America to serve the Italian immigrants. In America she founded hospitals, schools, and orphanages to take care of their needs.